vivax, there is renewed recognition of severe malaria, but an understanding of the factors influencing disease severity is limited and remains an important research topic. falciparum-infected individuals do not, and why clinical presentations differ between children and adults. Nevertheless, important questions remain regarding why some patients develop life-threatening conditions while the majority of P. Insights into its complex pathophysiology are emerging through a combination of autopsy, neuroimaging, parasite binding, and endothelial characterizations. Cerebral malaria coma is one of the most severe manifestations of P. The majority of malaria cases are caused by Plasmodium falciparum and Plasmodium vivax, which differ in virulence, red blood cell tropism, cytoadhesion of infected erythrocytes, and dormant liver hypnozoite stages. parasites, the pathogenesis of severe malaria is still not well understood. More than a century after the discovery of Plasmodium spp.
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